When removing spam messages from queue:
Spool file for 1uWOef-00000007Jma-3Nlj is locked (another process is handling this message)
Message 1uWOef-00000007Jma-3Nlj is locked

To remove the message:
Enter the exim directory:
cd /var/spool/exim/input
Find the message ID:
find . -name '*1uWOef-00000007Jma-3Nlj*'
example output:
[root@open input]# find . -name '*1uWOef-00000007Jma-3Nlj*'
./f/1uWOef-00000007Jma-3Nlj-H
./f/1uWOef-00000007Jma-3Nlj-D
and simply delete the messages:
rm -rf ./f/1uWOef-00000007Jma-3Nlj-H ./f/1uWOef-00000007Jma-3Nlj-D
that’s it, its no longer in queue:
exim -bp | grep 1uWOef-00000007Jma-3Nlj